RCT 的終點

隨機分配對照臨床試驗（RCT）及其統合分析

唯一可靠的是主要終點，因爲統計檢定力 0.8-0.9（人數）是依據主要終點計算的。


不可靠（因為多重比較，以及統計檢定力 << 0.8 容易有假陽性/假陰性的結果）：次要終點、其他探索性終點、交互作用（次群分析）、副作用、事後分析、二次分析。


複合主要終點：好處是能減少需要的人數；壞處是無法知道每一個成分的貢獻，而且必須要每一個成分的重要性類似、發生率類似、效果類似。

例如：

• MAKE（eGFR 下降至少 50%、洗腎、死亡）中的重要性是死亡 >> 洗腎 > eGFR 下降至少 50%。

• MACE（中風/心肌梗塞/冠狀動脈血管重建、死於心血管疾病）中的重要性是死亡（沒有包括在裏面） > 死於心血管疾病 >> 中風/心肌梗塞/冠狀動脈血管重建。

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